Evidence-Based Supplement Reviews
Every supplement on this page has been evaluated using published clinical trials in human Type 2 diabetes populations. We only include supplements with at least 2 randomized controlled trials.
Strong Evidence
Multiple RCTs, meta-analyses, consistent results
The most studied natural compound for blood glucose management with evidence approaching some prescription medications.
A1C and glucose reduction
Key Benefit
500mg 2-3x/day
Studied Dose
-0.5 to -0.9%
A1C Effect
Strong evidence for diabetic neuropathy relief. Modest effect on blood glucose levels.
Neuropathy symptom relief
Key Benefit
600mg/day
Studied Dose
-0.1 to -0.3%
A1C Effect
Well-established fiber supplement that reduces post-meal glucose spikes when taken before meals.
Post-meal glucose reduction
Key Benefit
5-10g before meals
Studied Dose
15-20% spike reduction
A1C Effect
Strong cardiovascular benefits and significant triglyceride reduction. Minimal direct effect on A1C.
Cardiovascular protection
Key Benefit
2-4g/day
Studied Dose
Minimal A1C effect
A1C Effect
Moderate Evidence
Some RCTs, generally positive but limited data
Some evidence for glucose improvement, but results are inconsistent across studies.
Insulin sensitivity
Key Benefit
200-1000mcg/day
Studied Dose
-0.2 to -0.6%
A1C Effect
Important for insulin function. Benefits most pronounced in those with magnesium deficiency.
Insulin sensitivity
Key Benefit
250-350mg/day
Studied Dose
-0.1 to -0.3%
A1C Effect
Benefits primarily seen in those who are vitamin D deficient. Test levels before supplementing.
Insulin secretion support
Key Benefit
1000-4000 IU/day
Studied Dose
-0.1 to -0.2%
A1C Effect
Modest evidence for blood sugar benefits. Use Ceylon variety to avoid coumarin concerns.
Glucose metabolism
Key Benefit
1-6g/day
Studied Dose
-0.1 to -0.3%
A1C Effect